Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Predator-Prey Interactions02:39

Predator-Prey Interactions

21.2K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.2K
Van der Waals Interactions01:24

Van der Waals Interactions

71.0K
Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.
71.0K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.6K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

7.4K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
7.4K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.1K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safe Reduction of Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rates Using Multidisciplinary Quality Improvement Efforts.

O&G open·2026
Same author

Training Pathways for Minimally Invasive Gynecologic Surgery: An Analysis of Residencies and Matched FMIGS Trainees.

Journal of surgical education·2025
Same author

Food waste in residential aged care: A scoping review.

Nutrition & dietetics : the journal of the Dietitians Association of Australia·2025
Same author

Neuropsychiatric diagnoses after montelukast initiation in paediatric patients with asthma.

Thorax·2024
Same author

Assessing Self-Rated Physical Health Scores Following Repeat Exposure to Anthropogenic and Natural Hazards in Houston, TX.

Disaster medicine and public health preparedness·2024
Same author

Nicotine use during late adolescence and young adulthood is associated with changes in hippocampal volume and memory performance.

Frontiers in neuroscience·2024

Related Experiment Video

Updated: Jan 27, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens
10:39

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

14.0K

Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI.

Chinmay Patel1, Courtney Thompson2, Megan Copley-Harris3

  • 1Clinical Professor of Nephrology, University of Pikeville-Kentucky College of Osteopathic Medicine, Division of Nephrology, Pikeville Medical Center, Pikeville, KY, USA.

Case Reports in Medicine
|April 3, 2019
PubMed
Summary

Sitagliptin combined with statins like simvastatin may cause rhabdomyolysis and severe acute kidney injury (AKI). Healthcare providers should monitor patients for these serious drug interaction risks.

More Related Videos

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
09:36

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans

Published on: March 23, 2019

7.6K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

13.1K

Related Experiment Videos

Last Updated: Jan 27, 2026

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens
10:39

Single Cell Measurements of Vacuolar Rupture Caused by Intracellular Pathogens

Published on: June 12, 2013

14.0K
Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
09:36

Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans

Published on: March 23, 2019

7.6K
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
10:10

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

13.1K

Area of Science:

  • Pharmacology
  • Nephrology
  • Clinical Toxicology

Background:

  • Sitagliptin is a common treatment for type 2 diabetes.
  • Statins, including simvastatin, are widely used for managing dyslipidemia.
  • Concurrent use of these medications is frequent in clinical practice.

Observation:

  • A 69-year-old male developed rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis after initiating sitagliptin while on chronic simvastatin therapy.
  • This potential drug interaction is not listed in the sitagliptin package insert.
  • A literature review identified six prior cases of rhabdomyolysis linked to sitagliptin-statin interactions, with only two cases of AKI, neither requiring dialysis.

Findings:

  • The reported case represents a severe manifestation of sitagliptin-statin-induced rhabdomyolysis, necessitating dialysis.
  • Previous reports indicate a risk of muscular toxicity, but severe AKI requiring dialysis appears rare.
  • The interaction between sitagliptin and statins, particularly simvastatin, warrants clinical attention.

Implications:

  • Healthcare professionals must be vigilant for potential rhabdomyolysis and AKI in patients taking both sitagliptin and statins.
  • Close patient monitoring for muscular symptoms and kidney function is crucial.
  • Further research is needed to fully elucidate the muscular toxicity risks associated with concurrent sitagliptin and statin use.