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Association between gallstone and cardio-cerebrovascular disease: Systematic review and meta-analysis

Shou-Feng Zhao1, Ai-Min Wang2, Xin-Juan Yu1

  • 1Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.

Experimental and Therapeutic Medicine
|April 3, 2019
PubMed

Insights

Gallstone disease (GD) is linked to a higher risk of cardio-cerebrovascular disease (CVD). This meta-analysis confirms GD increases both the incidence and prevalence of CVD, highlighting a significant health connection.

Area of Science:

  • Cardiovascular Medicine
  • Gastroenterology
  • Epidemiology

Background:

  • Growing evidence suggests a link between gallstone disease (GD) and cardio-cerebrovascular disease (CVD).
  • Understanding this association is crucial for comprehensive patient care and risk assessment.

Purpose of the Study:

  • To systematically review and quantify the association between gallstone disease and cardio-cerebrovascular disease.
  • To determine the extent to which GD impacts CVD incidence and prevalence.

Main Methods:

  • A systematic literature search was conducted across PubMed, EMBASE, and the Cochrane Library up to March 3rd, 2018.
  • Meta-analysis included 10 studies comprising 1,272,177 participants (5 prospective and 5 retrospective cohorts).

Main Results:

  • Gallstone disease was significantly associated with an increased risk of CVD incidence (HR=1.24, 95% CI: 1.17-1.31).
  • GD was also linked to a higher prevalence of CVD (unadjusted OR=1.23, 95% CI: 1.21-1.25).
  • The association may be modulated by factors such as age and sex.

Conclusions:

  • Gallstone disease is demonstrably associated with an elevated risk of both developing and having cardio-cerebrovascular disease.
  • These findings underscore the importance of evaluating for gallstone disease in patients with established cardio-cerebrovascular disease.

Keywords:
cardio-cerebrovascular diseasegallstone diseasemeta-analysissubgroup analysis

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