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Wheat allergy in patients with recurrent urticaria
Ying-Yang Xu1,2, Nan-Nan Jiang1, Li-Ping Wen1,2
1Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China.
The World Allergy Organization Journal
|April 3, 2019
Summary
Recurrent urticaria is common in wheat allergy patients, often preceding anaphylaxis. Screening for wheat allergy in urticaria patients can identify those at risk for severe reactions.
Area of Science:
- Allergy and Immunology
- Clinical Medicine
- Epidemiology
Background:
- Clinical observations suggest a link between recurrent urticaria and wheat-induced anaphylaxis (WIA)/wheat-dependent exercise-induced anaphylaxis (WDEIA).
- Understanding this association is crucial for early identification and management of patients at risk.
Purpose of the Study:
- To determine the association between a history of recurrent urticaria and the development of wheat allergy, including WIA and WDEIA.
- To investigate the temporal relationship and clinical characteristics of urticaria in patients with wheat allergy.
Main Methods:
- A population-based cohort study was conducted from 2009 to 2016.
- Data included patients with WIA/WDEIA, recurrent urticaria, non-wheat-related anaphylaxis, atopic disease, and healthy controls.
- Diagnostic methods involved medical records, questionnaires, serum specific IgE testing (wheat, gluten, ω-5 gliadin), and skin prick tests for wheat.
Main Results:
- A significant proportion of WIA/WDEIA patients (84.9%) had a history of recurrent urticaria, often preceding anaphylaxis (70.4%).
- Wheat allergy was diagnosed in 6.8% of patients with recurrent urticaria.
- Serum specific IgE to ω-5 gliadin was higher in WIA/WDEIA patients compared to those with wheat-induced urticaria.
Conclusions:
- Recurrent urticaria is a significant risk factor for wheat allergy and subsequent anaphylaxis.
- Screening for wheat allergy in patients with recurrent urticaria is recommended for early risk identification.
- Prompt diagnosis can lead to earlier intervention and potentially prevent severe allergic reactions.
Keywords:
Recurrent urticariaWDEIA, wheat-dependent exercise-induced anaphylaxisWIA, wheat-induced anaphylaxisWIU, wheat-induced urticariaWheat allergyWheat-dependent exercise-induced anaphylaxisWheat-induced anaphylaxisω-5 gliadinMore Related Videos
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