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Updated: Jan 27, 2026
08:42
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Spatiotemporal Case Cluster Analysis
Thomas Murphy1, Samuel Yang1, Richard Tucker1
1Department of Pediatrics, Women & Infants Hospital, Alpert Medical School of Brown University.
Pediatric Quality & Safety
|April 3, 2019
Summary
Statistical methods identified a necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) cluster in a NICU. The confirmed cluster was linked to increased births of small for gestational age infants and indomethacin use.
Area of Science:
- Neonatal intensive care unit (NICU) research
- Statistical epidemiology
- Clinical data analysis
Background:
- Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are critical neonatal conditions.
- Accurate identification of disease clusters is essential for timely intervention.
Purpose of the Study:
- To adapt and apply statistical methods for detecting NEC and SIP case clusters.
- To validate identified clusters through comprehensive data review.
Main Methods:
- Utilized a binomial distribution scan test to identify potential temporal clusters.
- Calculated incidence-density rates (IDR) to compare cluster incidence with baseline.
- Performed structured chart reviews and spatial analysis (Grimson Test).
Main Results:
- Identified one confirmed temporal cluster of NEC/SIP cases.
- No significant spatial clustering was observed.
- Confirmed cluster associated with increased small for gestational age births and indomethacin use.
Conclusions:
- Statistical methods effectively differentiate true disease clusters from random occurrences.
- Confirmed clusters necessitate further investigation, including spatial and clinical reviews.
- This methodology holds potential for application in other disease surveillance contexts.
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