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Pericytes in the Gut

Marta Ramirez1, Nuria Pell1, Marc Mejias1,2

  • 1Angiogenesis in Liver Disease Research Group, IDIBAPS Biomedical Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Advances in Experimental Medicine and Biology
|April 3, 2019
PubMed

Insights

This review explores gut pericytes and their role in chronic liver disease. It highlights their function in the gut-liver axis and pathological angiogenesis.

Area of Science:

  • Gastroenterology
  • Vascular Biology
  • Hepatology

Background:

  • Pericytes are crucial vascular cells in the gut.
  • Their role in chronic liver disease pathogenesis is increasingly recognized.
  • Understanding the gut-liver axis is vital for liver disease management.

Purpose of the Study:

  • To review current knowledge on gut pericytes in liver disease.
  • To elucidate pericyte-endothelial cell interactions and their pathological functions.
  • To explore the implications of the gut-liver axis in liver disease.

Main Methods:

  • Literature review of pericyte biology and liver disease.
  • Analysis of molecular signaling pathways involved in angiogenesis.
  • Examination of the gut-vascular barrier in liver pathology.

Main Results:

  • Pericytes significantly influence pathological angiogenesis in liver disease.
  • Pericyte dysfunction contributes to the breakdown of the gut-vascular barrier.
  • Molecular signaling pathways involving pericytes are key in liver disease progression.

Conclusions:

  • Pericytes are critical players in the gut-liver axis and liver disease.
  • Targeting pericyte function may offer therapeutic strategies for liver disease.
  • Further research into pericyte-mediated signaling is warranted.

Keywords:
Chronic liver diseaseGut-vascular barrierIntestinal circulationMesenteric vascular bedPathological angiogenesisPortosystemic collateral vessels

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