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Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
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Recent Advances in Scaffold Design and Material for Vascularized Tissue-Engineered Bone Regeneration
Shi Yin1,2,3, Wenjie Zhang1,2,3, Zhiyuan Zhang3
1Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639, Manufacturing Bureau Road, Huangpu District, Shanghai, China.
Advanced Healthcare Materials
|April 3, 2019
Summary
Developing vascularized bone scaffolds is crucial for bone tissue engineering. This review focuses on scaffold design, biomaterials, and modifications to enhance bone regeneration and vascularization for clinical applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bone tissue engineering requires synergistic interactions between osteogenesis and angioblasts for vascularization.
- Current strategies include cytokines, pre-vascularization, and co-culture, but scaffold development remains a challenge.
Purpose of the Study:
- To review advancements in biomaterial selection, scaffold preparation, and structural design for vascularized bone scaffolds.
- To propose future strategies focusing on microenvironment regulation for enhanced vascularized bone regeneration.
Main Methods:
- Review of existing literature on biomaterials, scaffold preparation, composition modification, and structural design.
- Analysis of synergistic modifications for vascular scaffolds in bone tissue engineering.
Main Results:
- Scaffold properties significantly impact the development of vascularized bone tissue.
- A comprehensive approach combining material selection, preparation, composition, and structural design is essential.
Conclusions:
- Optimizing scaffold design is key to achieving clinically relevant vascularized bone substitutes.
- Future research should prioritize regulating the microenvironment to promote vascularized bone regeneration.
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