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Updated: Jan 26, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Solid phase syntheses of peptoid like arylureido compounds and sequencing of isobars without molecular encoding
Kanwal Asif1, Gregory L O'Brien, Scott M Goodman
1Department of Chemistry, SUNY Buffalo State, 1300 Elmwood Ave, Buffalo, NY 14222, USA. suwals@buffalostate.edu.
Abstract:
Arylureido-backbone containing peptoid-like trimers were prepared using the one-bead-one-compound approach. Isobaric molecules were synthesized from isocyanate precursors that contain alkyl halide handles at the ortho and para-positions in the phenyl ring. After chain extension with a primary amine, the piperazine-capped molecules were sequenced using tandem mass spectrometry and successfully identified based on their fragmentation pattern without a need for internal molecular encoding.
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