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Effect of PET Image Reconstruction Techniques on Unexpected Aorta Uptake
Hassan Hirji1, Keith Sullivan2, Imran Lasker3
1Northwick Park Hospital, Department of Rheumatology, London, England
Molecular Imaging and Radionuclide Therapy
|April 3, 2019
Summary
Modern 18F-FDG PET/CT reconstruction algorithms did not significantly alter aorta uptake measurements. However, qualitative visual analysis revealed differences, suggesting potential impacts on image interpretation for aorta SUVmax and TBRmax.
Area of Science:
- Nuclear Medicine
- Radiology
- Medical Imaging
Background:
- Unexpected aorta uptake in 18F-FDG PET/CT can affect patient diagnosis.
- Modern reconstruction algorithms may influence image quality and quantitative values.
Purpose of the Study:
- To evaluate the impact of various reconstruction algorithms on aorta uptake in 18F-FDG PET/CT.
- To compare semi-quantitative and qualitative analyses of aorta uptake across different algorithms.
Main Methods:
- 25 patients without vascular disease underwent 18F-FDG PET/CT.
- Aorta and blood pool regions of interest were analyzed using iterative reconstruction (IT), IT+TOF, and UHD (with/without MAR) algorithms.
- Semi-quantitative SUVmax, SUVmean, and TBRmax were calculated; qualitative visual analysis was also performed.
Main Results:
- No statistically significant differences were found in aorta SUVmax, BP SUVmean, or TBRmax across reconstruction algorithms (p > 0.05).
- Qualitative visual analysis showed significant differences between IT+TOF and UHD/UHD+MAR reconstructions (p=0.02).
Conclusions:
- Reconstruction algorithms did not significantly impact semi-quantitative aorta uptake metrics.
- Qualitative assessment revealed significant differences, highlighting the importance of visual interpretation.
- Further studies with larger cohorts are recommended for technique harmonization.
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