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Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

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CCD Multi-Ion Image Sensor with Four 128 × 128 Pixels Array.

Toshiaki Hattori¹, Fumihiro Dasai², Hikaru Sato³

¹Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, Hibarigaoka 1-1, Tenpaku, Toyohashi 441-8580, Japan. thattori@ee.tut.ac.jp.

Sensors (Basel, Switzerland)

|April 4, 2019

Summary

This study developed a novel semiconductor array sensor capable of simultaneously imaging the concentration of four ions: hydrogen (H⁺), sodium (Na⁺), potassium (K⁺), and calcium (Ca²⁺). The sensor utilizes advanced imaging technologies for real-time ion analysis.

Keywords:

CCD ion sensor CMOS technology bioactive cations ink-jet printing multi-ion image

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Area of Science:

* Materials Science and Engineering
* Chemical Sensing Technologies
* Semiconductor Device Fabrication

Background:

* Current ion sensing methods often lack spatial resolution and simultaneous multi-ion detection capabilities.
* Developing integrated sensors for real-time monitoring of multiple biologically relevant ions is crucial for various applications.

Purpose of the Study:

* To fabricate and characterize a novel semiconductor array sensor for simultaneous imaging of H⁺, Na⁺, K⁺, and Ca²⁺.
* To evaluate the sensor's performance using complementary metal oxide semiconductor (CMOS) and charged coupled device (CCD) technologies.

Main Methods:

* Fabrication of a four-block semiconductor array sensor using CMOS and CCD technologies.
* Utilized silicon nitride (Si₃N₄) for H⁺ detection and inkjet printing of cation-sensitive membranes (Na⁺, K⁺, Ca²⁺ ionophores in PVC) for other blocks.
* Each 128x128 pixel block allowed independent calibration and simultaneous ion concentration imaging.

Main Results:

* Successfully fabricated a multi-ion sensing array with distinct regions for H⁺, Na⁺, K⁺, and Ca²⁺ detection.
* Demonstrated simultaneous ion concentration imaging at a rate of 8.3 frames per second.
* Achieved independent calibration for each sensing block under varied measurement conditions.

Conclusions:

* The developed semiconductor array sensor enables simultaneous, real-time imaging of multiple key ions.
* This technology offers a promising platform for advanced chemical sensing and in-situ monitoring applications.
* The sensor's design facilitates adaptable calibration, enhancing its utility across different experimental setups.