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Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors

Stephanie M Lauden1, Stella Chongwain2, Anzeh Achidi2

  • 1Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.

BMC Research Notes
|April 4, 2019
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in West African blood donors, affecting 7.9%. G6PD deficiency may be linked to increased exposure to certain infectious diseases like hepatitis C and syphilis.

Area of Science:

  • Hematology
  • Genetics
  • Epidemiology

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most prevalent enzymopathy globally.
  • It disproportionately affects individuals of African descent, potentially leading to severe hemolytic reactions.
  • Its prevalence and impact on morbidity in West Africa remain under-researched.

Purpose of the Study:

  • To determine the prevalence of G6PD deficiency among West African blood donors.
  • To explore potential associations between G6PD deficiency and infectious disease markers in this population.

Main Methods:

  • A cross-sectional study was conducted on 1001 adult male blood donors in Cameroon.
  • G6PD deficiency status was assessed.
  • Donors were screened for infectious diseases including Hepatitis C virus (HCV), syphilis (RPR), Hepatitis B surface antigen (HBsAg), HIV-1, and HIV-2.

Main Results:

  • The prevalence of G6PD deficiency among the study participants was 7.9%.
  • No significant differences in hemoglobin levels or ABO blood subtypes were observed between G6PD-normal and deficient individuals.
  • G6PD-deficient donors showed a higher likelihood of screening positive for HCV and syphilis compared to G6PD-normal donors.

Conclusions:

  • G6PD deficiency is a common condition in West African male blood donors.
  • The findings suggest a potential association between G6PD deficiency and exposure to specific infectious agents, warranting further investigation.
Abstract

Keywords:
AfricaBlood donorG6PD deficiency

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