Related Experiment Video
Updated: Jan 26, 2026

Patch Clamp Recordings in Inner Ear Hair Cells Isolated from Zebrafish
Published on: October 17, 2012
A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth
Guang Yang1,2,3,4, Qian Chen1,2,3, Di Wen1,2,3
1Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.
Abstract:
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.
Related Concept Videos
Hair Cells
Accessory Structures of the Skin: Hair and Hair Follicles
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Accessory Structures of the Skin: Hair Growth and Types
The Eukaryotic Promoter Region
The Eukaryotic Promoter Region
Long-patch Base Excision Repair

