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Updated: Jan 26, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Anti-aging and hydration efficacy of a cross-linked hyaluronic acid microstructure patch
Ye Jin Lee1, Hak Tae Kim2, Woo Jin Lee2
1Department of Dermatology, Kyunghee University hospital at Gangdong, Seoul, Republic of South Korea.
Abstract:
This study evaluated the safety and efficacy of biodegradable microstructure patches composed of cross-linked hyaluronic acid (CLHA). A primary skin irritation test showed that the CLHA patches were not an irritant, whereas a clinical study showed that application of single CLHA patches significantly improved skin hydration at the periorbital region for 3 days and at the nasolabial fold for 6 days. Patch application also improved superficial wrinkles at the periorbital region for 3 days and at the nasolabial fold for 1 day. The absence of side effects indicated that application of these CLHA microstructure patches is both safe and convenient for moisturization and anti-wrinkle effects.
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