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Action of Reverse T3 on Cancer Cells.

Hung-Yun Lin1,2,3,4, Heng-Yuan Tang5, Matthew Leinung6

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|April 4, 2019
PubMed
Summary
This summary is machine-generated.

Reverse T3 (rT3), a thyroid hormone analog, surprisingly promotes the growth of human breast cancer and glioblastoma cells in vitro. This finding suggests rT3 may play a role in supporting cancer progression.

Keywords:
3,3',5’-triiodo-L-thyronineIntegrin αvβ3L-thyroxinebreast cancerglioblastoma

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is a naturally occurring thyroid hormone analog.
  • rT3 binds to integrin αvβ3, a receptor highly expressed on tumor cells.
  • Integrin αvβ3 is implicated in cancer cell proliferation stimulated by L-thyroxine (T4).

Purpose of the Study:

  • To investigate the effect of rT3 on cancer cell proliferation.
  • To determine if rT3 influences the growth of human breast cancer and glioblastoma cells.

Main Methods:

  • In vitro cell culture experiments.
  • Assessing cell proliferation rates in response to rT3 exposure.

Main Results:

  • rT3 significantly increased proliferation of human breast cancer cells by 50-80% (P < 0.05-0.001).
  • rT3 also significantly increased proliferation of glioblastoma cells by 50-80% (P < 0.05-0.001).

Conclusions:

  • rT3 demonstrates a pro-proliferative effect on cancer cells.
  • rT3 may function as a host factor that supports tumor growth.
  • Further research is warranted to explore the role of rT3 in cancer.