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The Muddied Waters of Ibrutinib Therapy
Miri Schamroth Pravda1, Nili Schamroth Pravda2, Michael Lishner3
1Department of Internal Medicine A, Meir Medical Center, Kfar Saba, Israel, Miripravda@gmail.com.
Abstract:
A 37-year-old male was admitted with an atypical presentation of central nervous system (CNS) aspergillosis while on ibrutinib therapy for a CNS relapse of mantle cell lymphoma. This case highlights the importance of a high clinical suspicion of opportunistic infections in patients receiving small-molecule kinase inhibitors. This report includes a review of reported cases of Aspergillus infections in patients receiving ibrutinib and the shared features of these cases.
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