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Updated: Jan 26, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

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CD91 on dendritic cells governs immunosurveillance of nascent, emerging tumors

Abigail L Sedlacek1, Theodore P Younker2, Yu Jerry Zhou3

  • 1Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

JCI Insight
|April 5, 2019
PubMed

Insights

The immune system uses CD91 (cluster of differentiation 91) to detect and eliminate early cancer cells. Its absence amplifies tumor growth and progression, highlighting CD91

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • The immune system, particularly T cells, plays a crucial role in preventing cancer by eliminating aberrant cells.
  • Deficiencies in immune surveillance are linked to increased cancer incidence.
  • Antigen-presenting cells (APCs) are key mediators of immune responses against nascent tumors.

Purpose of the Study:

  • To investigate the role of CD91 (cluster of differentiation 91) in immune responses to nascent tumors.
  • To elucidate the molecular mechanism by which CD91 influences cancer immunosurveillance.
  • To determine if CD91 function impacts tumor immunogenicity and patient outcomes.

Main Methods:

  • Utilized mouse models to study the role of CD91 in tumor development and immune responses.
  • Analyzed immune cell activity and effector functions in the presence and absence of CD91.
  • Examined tumor neo-epitope expression and immunogenicity.
  • Investigated the impact of human CD91 polymorphisms on antitumor immunity in cancer patients.

Main Results:

  • CD91 is essential for priming effective immune responses against emerging tumors.
  • Absence of CD91 leads to suppressed effector immune responses and increased tumor incidence and progression.
  • Tumors developing without CD91 exhibit enhanced immunogenicity due to altered neo-epitope expression.
  • Human CD91 polymorphisms correlate with altered antitumor immune responses in cancer patients.

Conclusions:

  • CD91 acts as a critical receptor for initiating immune surveillance against nascent tumors.
  • CD91 deficiency compromises the immune system's ability to control early-stage cancer.
  • CD91's role in priming antitumor immunity makes it a potential predictor of cancer susceptibility and progression.
Keywords:
Adaptive immunityAntigen presentationCancerImmunology

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