Jove
Visualize
Contact Us

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

9.6K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
9.6K
Autophagic Cell Death01:18

Autophagic Cell Death

4.4K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.4K
Brain Waves01:23

Brain Waves

4.0K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.0K
Organization of the Brain01:30

Organization of the Brain

2.5K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
2.5K
Brain Imaging01:14

Brain Imaging

703
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
703
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

8.6K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to commentaries: 'Further clarity on cooperation and morality'.

Journal of medical ethics·2017
Same author

Further clarity on cooperation and morality.

Journal of medical ethics·2016
Same journal

The mechanics of epistemic justice: a response to Toding et al. and their application of my epistemic approach to dignity.

Theoretical medicine and bioethics·2026
Same journal

Flourishing within vulnerability: on human fragility and the conditions for a habitable environment.

Theoretical medicine and bioethics·2026
Same journal

Camouflaging in autism as a dual-normative construct: a philosophical critique.

Theoretical medicine and bioethics·2026
Same journal

The last low whispers revisited: a reply to Sulmasy on palliative sedation.

Theoretical medicine and bioethics·2026
Same journal

Epistemic justice and the moral status of the dead.

Theoretical medicine and bioethics·2026
Same journal

Practical wisdom in medicine: defending a multidimensional, integrated view of an indispensable virtue.

Theoretical medicine and bioethics·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 26, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
05:03

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

5.9K

Death, unity, and the brain.

David S Oderberg1

  • 1Department of Philosophy, University of Reading, Reading, RG6 6AA, UK. d.s.oderberg@reading.ac.uk.

Theoretical Medicine and Bioethics
|April 5, 2019
PubMed
Summary
This summary is machine-generated.

The dead donor rule permits organ removal only after death. Current death criteria, brain death and circulatory death, are inadequate. Bodily decomposition is the only sure sign of death, allowing for ethical organ donation.

Keywords:
Bodily integrationBrain deathDeathHylemorphismOrgan donation

More Related Videos

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.5K
Author Spotlight: Imaging Pericytes Post-Subarachnoid Hemorrhaging in Rodents
05:11

Author Spotlight: Imaging Pericytes Post-Subarachnoid Hemorrhaging in Rodents

Published on: August 18, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy
05:03

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

5.9K
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
10:36

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons

Published on: November 6, 2017

8.5K
Author Spotlight: Imaging Pericytes Post-Subarachnoid Hemorrhaging in Rodents
05:11

Author Spotlight: Imaging Pericytes Post-Subarachnoid Hemorrhaging in Rodents

Published on: August 18, 2023

1.7K

Area of Science:

  • Philosophy of Medicine
  • Bioethics
  • Metaphysics

Background:

  • The dead donor rule prohibits organ retrieval from living individuals without consent.
  • Current medical and philosophical definitions of death are debated.
  • Ethical organ donation hinges on accurate determination of death.

Purpose of the Study:

  • To investigate a metaphysically sound and clinically relevant definition of human death.
  • To determine if such a definition could ethically permit organ donation.
  • To critically analyze existing criteria for determining death.

Main Methods:

  • A neo-Aristotelian theory of death is proposed, defining death as the separation of the soul (organizing principle) from the body.
  • This theory is elaborated as the loss of organismic integrity.
  • Empirical and metaphysical inadequacies of brain death and circulatory death criteria are examined.

Main Results:

  • Brain death and circulatory death criteria are found to be both empirically and metaphysically insufficient.
  • These criteria lack significant epistemic value as definitions of death.
  • A significant mismatch exists between the metaphysical nature of death and current clinical/philosophical criteria.

Conclusions:

  • Only actual bodily decomposition serves as a definitive sign of human death.
  • Current criteria for determining death are inadequate for ethical organ donation.
  • A revised understanding of death is necessary to reconcile medical practice with philosophical accuracy.