Related Experiment Video
Updated: Jan 26, 2026

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
19 F Magic Angle Spinning Dynamic Nuclear Polarization Enhanced NMR Spectroscopy
Jasmine Viger-Gravel1, Claudia E Avalos1, Dominik J Kubicki1
1Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
Abstract:
The introduction of high-frequency, high-power microwave sources, tailored biradicals, and low-temperature magic angle spinning (MAS) probes has led to a rapid development of hyperpolarization strategies for solids and frozen solutions, leading to large gains in NMR sensitivity. Here, we introduce a protocol for efficient hyperpolarization of 19 F nuclei in MAS DNP enhanced NMR spectroscopy. We identified trifluoroethanol-d3 as a versatile glassy matrix and show that 12 mm AMUPol (with microcrystalline KBr) provides direct 19 F DNP enhancements of over 100 at 9.4 T. We applied this protocol to obtain DNP-enhanced 19 F and 19 F-13 C cross-polarization (CP) spectra for an active pharmaceutical ingredient and a fluorinated mesostructured hybrid material, using incipient wetness impregnation, with enhancements of approximately 25 and 10 in the bulk solid, respectively. This strategy is a general and straightforward method for obtaining enhanced 19 F MAS spectra from fluorinated materials.
More Related Videos
Related Concept Videos
NMR Spectroscopy: Spin–Spin Coupling
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
Atomic Nuclei: Nuclear Spin
Atomic nuclei have a net nuclear spin, , which can have an integer or half-integer value. In atomic nuclei, the spins of protons are paired against each other but not with neutrons, and vice versa. Consequently, an even number of protons does not contribute to...
NMR Spectroscopy Of Amines
Nuclear Stability
To hold positively charged protons together...
Atomic Nuclei: Nuclear Spin State Overview

