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Related Experiment Video

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Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
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Rheumatologic Diseases and the Liver.

Agazi Gebreselassie1, Farshad Aduli2, Charles D Howell3

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Howard University Hospital, 2041 Georgia Avenue Northwest, Suite 4J19, Washington, DC 20060, USA.

Clinics in Liver Disease
|April 6, 2019
PubMed
Summary

Rheumatologic diseases can impact the liver, with shared immune pathways linking autoimmune liver conditions and systemic autoimmune disorders. Medications for rheumatologic conditions may also cause liver issues.

Keywords:
Autoimmune liver diseaseElevated liver enzymesHepatotoxicityLiver injuryRheumatologic diseases

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Area of Science:

  • Hepatology
  • Rheumatology
  • Immunology

Background:

  • Rheumatologic disorders frequently involve the liver, exhibiting shared epidemiologic, genetic, and immunologic characteristics with autoimmune liver diseases.
  • Conditions like primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis are more prevalent in patients with systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, systemic sclerosis, and vasculitis.
  • Non-immune-mediated rheumatologic conditions, such as gouty arthritis, can also manifest with hepatic involvement.

Purpose of the Study:

  • To explore the intricate relationship between rheumatologic diseases and liver involvement.
  • To highlight the overlap between immune-mediated rheumatologic conditions and autoimmune liver diseases.
  • To discuss the hepatic manifestations of both immune-mediated and non-immune-mediated rheumatologic disorders.

Main Methods:

  • Review of existing literature on rheumatologic disorders and liver diseases.
  • Analysis of epidemiologic, genetic, and immunologic connections.
  • Examination of clinical presentations and therapeutic implications.

Main Results:

  • Significant overlap exists between immune-mediated rheumatologic disorders and autoimmune liver diseases.
  • Autoimmune liver diseases show increased frequency in patients with various systemic autoimmune conditions.
  • Medications used for rheumatologic diseases can lead to liver dysfunction.
  • Liver disorders can also present with rheumatologic symptoms.

Conclusions:

  • There is a substantial bidirectional relationship between rheumatologic and hepatic disorders.
  • Understanding these connections is crucial for comprehensive patient management.
  • Further research into shared pathways may reveal novel therapeutic targets.