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Updated: Jan 26, 2026

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Pore size effect on adsorption and release of metoprolol tartrate in mesoporous silica: Experimental and molecular

Shicheng Luo1, Jiakang Hao1, Yanmei Gao1

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, PR China.

Materials Science & Engineering. C, Materials for Biological Applications
|April 6, 2019
PubMed

Insights

Mesoporous silica nanoparticles with larger pores effectively carry metoprolol tartrate for sustained release. A pH-sensitive system was developed for potential morning hypertension treatment.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Mesoporous silica nanoparticles (MSNs) are explored for sustained drug delivery.
  • Metoprolol tartrate (MPT) delivery is limited by bulky molecules and small MSN pores (3-6 nm).

Purpose of the Study:

  • To investigate the effect of MSN pore size on metoprolol tartrate (MPT) adsorption and release.
  • To develop a pH-sensitive MPT drug delivery system for potential hypertension treatment.

Main Methods:

  • Synthesized two types of MCF-26 mesoporous silica nanoparticles with pore sizes of 11 nm and 15 nm.
  • Compared MPT release from MCF-26, MCM-41, and SBA-15 MSNs using molecular simulation and experimental release studies.
  • Coated MPT-loaded MCF-26 nanoparticles with an enteric polymer to create a pH-sensitive system.

Main Results:

  • Larger pore sizes (11-15 nm) in MCF-26 MSNs improved MPT adsorption and sustained release compared to MCM-41 and SBA-15.
  • Molecular simulations and release experiments confirmed the pore size effect on MPT diffusion.
  • A functional pH-sensitive drug delivery system was successfully fabricated.

Conclusions:

  • MCF-26 MSNs with optimized pore sizes are suitable carriers for metoprolol tartrate sustained release.
  • The developed pH-sensitive system shows promise for managing morning hypertension attacks via oral administration before sleep.
Keywords:
Drug deliveryMesoporous silicaMolecular simulationPolymer coatingpH-sensitive

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