Related Experiment Video

Updated: Jan 26, 2026

Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System
08:47

Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System

Published on: October 19, 2015

9.3K

Management of bioprosthetic cardiac valve thrombosis

Jerry Fan1, Kirill Lipatov1, Wes Lane2

  • 1Department of Internal Medicine, Baylor Scott and White HealthTempleTexas.

Proceedings (Baylor University. Medical Center)
|April 6, 2019
PubMed

Insights

Bioprosthetic valve thrombosis, a complication within a year of replacement, is visualized by 4D CT. New trials suggest single antiplatelet or anticoagulant therapy for treatment, challenging current guidelines.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Valvular thrombosis is a recognized complication following bioprosthetic heart valve replacement, typically manifesting within the first year post-implantation.
  • Current prophylactic strategies involve aspirin for all bioprosthetic valve recipients, dual antiplatelet therapy for aortic valve replacements, and anticoagulation for mitral valve replacements.

Observation:

  • Four-dimensional computed tomography (4D CT) is emerging as the preferred imaging modality for direct visualization of thrombus.
  • The study presents three distinct cases illustrating the clinical application of anticoagulants and advanced imaging techniques for thrombus detection.

Findings:

  • Recent clinical trials indicate that single-agent antiplatelet therapy or anticoagulation may be effective treatments for established bioprosthetic valve thrombosis.
  • These findings challenge the existing prophylactic guidelines, suggesting a potential shift in therapeutic approaches.

Implications:

  • The evolving understanding of bioprosthetic valve thrombosis necessitates a re-evaluation of current treatment and prophylaxis guidelines.
  • Advanced imaging like 4D CT, combined with novel therapeutic strategies, offers improved management options for patients with bioprosthetic heart valves.

Keywords:
Anticoagulationbioprosthetic valve replacementthrombosis

More Related Videos

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

13.4K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

3.2K

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
521
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
234
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
341
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
704
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
439
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.5K