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Immunomagnetic Separation of Fat Depot-specific Sca1high Adipose-derived Stem Cells ASCs
Published on: August 11, 2016
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Adipose-derived stromal/stem cells from different adipose depots in obesity development
Karina Ribeiro Silva1, Leandra Santos Baptista1
1Laboratory of Tissue Bioengineering, Directory of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology, Duque de Caxias, RJ 25250-020, Brazil.
World Journal of Stem Cells
|April 6, 2019
Summary
Obesity increases risks for cardiovascular and metabolic diseases due to white adipose tissue (WAT) dysfunction. Depot-specific adipose-derived stem/stromal cells (ASC) drive WAT heterogeneity and contribute to obesity
Area of Science:
- Cell Biology
- Metabolic Disease Research
- Obesity Pathophysiology
Background:
- Obesity is a growing global health concern, linked to cardiovascular and metabolic diseases like type 2 diabetes.
- White adipose tissue (WAT) dysfunction contributes to comorbidities by affecting metabolism, insulin sensitivity, and inflammation.
- WAT depots exhibit heterogeneity in morphology and function, influencing homeostasis and obesity development.
Purpose of the Study:
- To review the depot-specific properties of adipose-derived stem/stromal cells (ASC).
- To elucidate how these ASC properties contribute to the pathophysiology of obesity and metabolic disorders.
- To guide the development of ASC-based therapeutic strategies for obesity-related conditions.
Main Methods:
- Literature review focusing on depot-specific ASC characteristics.
- Analysis of studies investigating ASC gene expression, adipogenic, and immunomodulatory potentials.
- Synthesis of evidence linking ASC behavior to WAT heterogeneity and metabolic dysfunction.
Main Results:
- Adipose-derived stem/stromal cells (ASC) display distinct profiles across different WAT depots (subcutaneous, visceral).
- Depot-specific ASCs possess unique gene expression patterns and varying adipogenic and immunomodulatory capacities.
- These cellular differences are key drivers of WAT functional heterogeneity and depot-specific responses to metabolic challenges.
Conclusions:
- Depot-specific ASCs play a critical role in the development of obesity and associated metabolic diseases.
- Understanding these cell-specific properties is essential for targeted therapeutic interventions.
- Further research into ASC-based approaches holds promise for managing obesity and its comorbidities.
Keywords:
Adipose depotAdipose-derived stromal/stem cellsInflammationMetabolic diseasesObesityWhite adipose tissueMore Related Videos
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