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Published on: June 7, 2015
5‑Fluorouracil loaded chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel as a potential anticancer drug
Mohammad Sadegh Amini-Fazl1, Reza Mohammadi2, Karim Kheiri2
1Research Laboratory of Advanced Polymer Material, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran..
Abstract:
In most cancer treatments, chemotherapy is currently necessary; hence, more attention was devoted to developing new methods for designing drug delivery systems (DDS) with controlled drug release. For this aim, anticancer 5‑fluorouracil (5-FU) drug was loaded into chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel (CS/PAA/Fe3O4) through immersing in the drug solution. The prepared CS/PAA/Fe3O4 was characterized using FT-IR, XRD, VSM, TGA and SEM analysis. For demonstrating the efficiency of the prepared novel nanocomposite carrier as a controlled DDS, in-vitro the drug delivery tests were carried out in mimicking the colon and rectal conditions. The drug release tests showed that the CS/PAA/Fe3O4 enhanced the stability of drug dosing for a long time with controlled releases in the colon and rectal conditions. According to the obtained results, the prepared nanocomposite hydrogel could potentially to be used in DDS as a colon and rectal administration of 5-FU.
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