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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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Emerging role of PI3K/AKT in tumor-related epigenetic regulation

Qi Yang1, Wei Jiang2, Peng Hou1

  • 1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Seminars in Cancer Biology
|April 6, 2019
PubMed

Insights

The phosphatidylinositol 3-kinase (PI3K)/AKT pathway influences cancer development by altering epigenetic mechanisms like DNA methylation and histone modifications. This review explores how PI3K/AKT signaling impacts cancer epigenetics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Epigenetic alterations are crucial in cancer initiation and progression, alongside genetic changes.
  • Key epigenetic mechanisms include DNA methylation, histone modifications, and RNA-mediated regulation.
  • These processes are controlled by chromatin-associated proteins and influenced by signaling pathways.

Purpose of the Study:

  • To review how the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway modulates epigenetic reprogramming in cancer.
  • To establish the link between the PI3K/AKT cascade and the cancer epigenome.

Main Methods:

  • Literature review of studies on PI3K/AKT signaling and epigenetic modifiers in cancer.
  • Analysis of mechanisms by which PI3K/AKT influences DNA methylation, histone modifications, and RNA regulation.
  • Examination of the role of these interactions in cancer initiation and progression.

Main Results:

  • The PI3K/AKT pathway is frequently activated in human cancers and regulates multiple biological processes.
  • Evidence shows PI3K/AKT signaling directly or indirectly modulates critical epigenetic modifiers.
  • These modulations contribute to the oncogenic functions of the PI3K/AKT pathway in various cancers.

Conclusions:

  • The PI3K/AKT pathway plays a significant role in cancer development through epigenetic reprogramming.
  • Understanding the interplay between PI3K/AKT signaling and the epigenome is vital for cancer research.
  • Targeting this crosstalk may offer novel therapeutic strategies for cancer treatment.
Keywords:
DNA methylationEpigenetic modificationsHistone methylation/acetylationNon-coding RNAsPI3K/AKT pathway

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