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Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells
Published on: September 24, 2017
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The Blood-Brain Barrier: Implications for Vasculitis.
1Department of Neurology, Division of Neuro-Epidemiology, New York University School of Medicine, New York, NY 10016, USA; School of Public Health, City University of New York, New York, NY, USA.
Neurologic Clinics
|April 7, 2019
Summary
The blood-brain barrier is crucial for brain development and function, not just a static barrier. Its breakdown is linked to neurological diseases and central nervous system vasculitis.
Area of Science:
- Neuroscience
- Vascular Biology
- Neurology
Background:
- The blood-brain barrier (BBB) was historically viewed as a static protective layer in adults.
- Emerging research highlights its dynamic role in neurodevelopment and cerebrovascular angiogenesis.
- BBB dysfunction is increasingly implicated in primary neurological disorders.
Purpose of the Study:
- To critically analyze the role of blood-brain barrier breakdown in neurological diseases.
- To review the historical perspective, neurodevelopmental significance, and functional aspects of the BBB.
- To explore the BBB's relevance to central nervous system vasculitis.
Main Methods:
- Literature review and synthesis of existing research on the blood-brain barrier.
- Analysis of historical data and contemporary findings on BBB function and dysfunction.
- Correlation of BBB alterations with clinicopathologic findings in neurological conditions.
Main Results:
- The BBB is dynamically functional throughout development and essential for angiogenesis.
- Blood-brain barrier breakdown is a significant factor in various primary neurological diseases.
- The BBB's integrity and dysfunction are critically relevant to central nervous system vasculitis.
Conclusions:
- The blood-brain barrier is a vital, dynamic component of the central nervous system.
- Understanding BBB breakdown is key to analyzing and treating neurological diseases, including vasculitis.
- Further research into BBB pathophysiology is essential for therapeutic advancements.
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