Effect of vagotomy on TRH inhibition of acid gastric secretion

The effect of slow (600 micrograms) and rapid (200 micrograms) infusion of TRH on acid gastric secretion was studied in a group of healthy volunteers and a group of patients treated by truncal vagotomy. It was shown that the slow (600 micrograms) TRH infusion does not act on gastric secretion in both groups, while the rapid (200 micrograms) TRH infusion appears to significantly decrease the parameters under study during the first 15 minutes of gastric juice collection.