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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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X-ray Crystallography02:18

X-ray Crystallography

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The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Microbial Morphologies01:29

Microbial Morphologies

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Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
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Physiological Barriers01:25

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
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Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Preparing Adherent Cells for X-ray Fluorescence Imaging by Chemical Fixation
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Imaging cell morphology and physiology using X-rays.

Venera Weinhardt1,2, Jian-Hua Chen1, Axel Ekman1

  • 1Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, U.S.A.

Biochemical Society Transactions
|April 7, 2019
PubMed
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This summary is machine-generated.

X-ray microscopy offers high-quality morphometric data for cell biology. Combining X-ray data with other imaging methods provides comprehensive biological system views.

Keywords:
X-ray tomographycell structureimaging

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Area of Science:

  • Cell Biology
  • Biomedical Imaging
  • Microscopy

Background:

  • Morphometric measurements are crucial in cell biology and medicine.
  • Traditionally, light and electron microscopy provided morphometric data.
  • X-ray microscopy is emerging as a powerful tool for quantitative biological imaging.

Purpose of the Study:

  • To review the current status of X-ray microscopy in quantitative biological imaging.
  • To describe the integration of X-ray microscopy with other imaging modalities.
  • To highlight the benefits of multimodal imaging for biological system analysis.

Main Methods:

  • Review of X-ray microscopy techniques for biological samples.
  • Description of data fusion strategies combining X-ray microscopy with fluorescence microscopy or spectromicroscopy.
  • Utilizing X-ray tomography for structural information.

Main Results:

  • X-ray microscopy provides high-quality morphometric information.
  • Combining X-ray data with other modalities generates polychromatic views.
  • Multimodal approaches yield more complete system understanding than single methods.

Conclusions:

  • X-ray microscopy is a valuable quantitative imaging modality.
  • Multimodal imaging, integrating structural and molecular data, enhances biological insights.
  • Combining physiological and morphological data creates more accurate biological models.