Related Experiment Video
Updated: Jan 26, 2026

In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
Advances in the treatment of coronary perforations
Iosif Xenogiannis1, Emmanouil S Brilakis1
1Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota.
Insights
Coronary artery perforation, a rare but serious complication of percutaneous coronary intervention, can now be better managed. New, more deliverable covered stents offer improved treatment options for large vessel perforations.
Area of Science:
- Interventional Cardiology
- Cardiovascular Surgery
- Medical Device Technology
Background:
- Coronary artery perforation is a rare yet life-threatening complication during percutaneous coronary intervention.
- Four types of coronary perforation exist: large vessel, distal vessel, septal collateral, and epicardial collateral.
Discussion:
- The previously available Graftmaster stent in the US had a high profile, making it difficult to deliver and expand.
- The Graftmaster stent was associated with high rates of in-stent restenosis and stent thrombosis.
- Newer covered stents like BeGraft and PK Papyrus offer improved deliverability.
Key Insights:
- The development of more accessible covered stents significantly enhances treatment options for coronary artery perforations.
- Improved stent technology addresses limitations of previous devices, potentially reducing complications.
- The PK Papyrus stent recently received FDA approval, expanding clinical choices.
Outlook:
- Wider availability and use of improved covered stents are expected to facilitate better outcomes for patients with coronary artery perforations.
- Further research may focus on long-term efficacy and safety of new covered stent technologies.
- Advancements in covered stent design could lead to reduced procedural complications and improved patient recovery.
Abstract:
Coronary artery perforation is an infrequent, but potentially life-threatening complication of percutaneous coronary intervention. There are four types of coronary perforation: (a) large vessel; (b) distal vessel; (c) septal collateral; and (d) epicardial collateral perforation. Implantation of a covered stent is the cornerstone of large vessel perforation treatment and can be used in some distal vessel perforations, when embolization is not feasible. Until now the only available covered stent in the US was the Graftmaster stent (two bare metal stents with a PTFE membrane in-between them), that has high profile and is challenging to deliver and expand. Use of the Graftmaster has been associated with high rates of in-stent restenosis and stent thrombosis. Availability of more deliverable covered stents, such as the BeGraft (Bentley InnoMed GmbH, Hechingen, Germany) and PK Papyrus (BIotronik, Lake Oswego, Oregon, that recently received FDA approval) will greatly facilitate treatment of large vessel coronary perforations.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Extraction: Advanced Methods
Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
Coronary Artery Disease I: Introduction

