Related Experiment Video
Updated: Jan 26, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
Published on: August 20, 2013
Editorial Commentary: Meniscal Tears or Meniscal Aging-That Is the Question
1Rush University Medical Center (B.J.C.).
Abstract:
Meniscal tears constitute one of the most common pathologies in sports medicine. Although frequently grouped by shape, location, and size for didactic purposes, considering them according to their cause is probably the single most important factor to predict their behavior and prognosis. For instance, an acute traumatic tear and a degenerative tear of the meniscus are located on opposite ends of the spectrum of the meniscal pathology (which is comparable to focal chondral defects and osteoarthritis). For this reason, surgically addressing a non-obstructive degenerative meniscus does not always address the cause of the problem (inherent catabolic state) or the character of the symptoms (due to concomitant osteoarthritis or overload), and therefore, outcomes have been reported to be unpredictable. Of note, several recent randomized clinical trials allowed for a single-way crossover, which could act as a major confounder related to patient recruitment and expectation bias. Considering these thoughts along with the associated media coverage, there is a global trend to treat degenerative tears with a more conservative approach. Despite this, the most appropriate treatment for patients with symptomatic degenerative tears for which a trial of conservative measures failed is yet to be determined.
Related Concept Videos
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
The Effect of Aging on Tissues
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

