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Personalized Medicine and Pediatric Asthma

Nathan M Pajor1, Theresa W Guilbert2

  • 1Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7041, Cincinnati, OH 45229, USA.

Immunology and Allergy Clinics of North America
|April 8, 2019
PubMed

Insights

Asthma management is improving through a personalized, phenotype-based approach. Understanding specific asthma types and utilizing targeted therapies will enhance treatment outcomes for children.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Asthma is a complex respiratory condition with diverse clinical presentations.
  • Recent research highlights the importance of identifying specific asthma phenotypes.
  • A phenotype-based approach tailors management to individual patient and disease characteristics.

Purpose of the Study:

  • To review the evidence supporting a phenotype-based approach to asthma management.
  • To discuss the implications of emerging therapies and phenotypic markers for pediatric asthma.
  • To underscore the potential for improved asthma control through personalized medicine.

Main Methods:

  • Literature review of studies on asthma phenotypes and treatment strategies.
  • Analysis of current and emerging therapeutic options for pediatric asthma.
  • Examination of advancements in phenotypic markers for asthma classification.

Main Results:

  • Evidence supports that asthma heterogeneity necessitates tailored treatment strategies.
  • A growing number of targeted therapies are becoming available for pediatric asthma.
  • New phenotypic markers are enhancing the ability to classify asthma subtypes.

Conclusions:

  • A phenotype-based approach is crucial for optimizing asthma management.
  • Personalized medicine, driven by phenotypic understanding, promises better outcomes for children with asthma.
  • Future advancements in therapies and biomarkers will further refine asthma care.

Keywords:
AdolescentBiologicsPediatric asthmaPersonalized medicinePreschoolSchool-age

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