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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis

Tanaya Bhowmick¹, Charles Liu², Brandon Imp²

¹Division of Allergy, Immunology and Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 362, New Brunswick, NJ, 08901, USA. Bhowmita@rwjms.rutgers.edu.

|April 8, 2019

Abstract

Introduction:

Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) is a major cause of morbidity and mortality in hospitalized patients. Ceftaroline fosamil (CPT) is the only available beta-lactam antibiotic with in vitro and in vivo activities against MRSA. There is currently limited clinical experience with CPT in complicated MRSA BSI.

Materials And Methods:

We report a series of eight patients, including three whose strains had reduced susceptibility to vancomycin.

Results:

CPT monotherapy was successfully used as salvage therapy for complicated MRSA BSI. The median time to documented clearance was 7 days.

Conclusion:

Ceftaroline monotherapy is effective for clearance of refractory MRSA BSI related to implanted devices, endocarditis, and orthopedic infections.

Keywords:

Bacteremia Ceftaroline Endocarditis MRSA VISA

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