When and How to Diagnose and Treat Vitamin D Deficiency in Adults: A Practical and Clinical Update

Vitamin D deficiency is considered a major public health concern. Inadequate sun exposure, limited oral intake, and impaired intestinal absorption are common risk factors for vitamin D deficiency. An increasing amount of research is aimed at answering questions regarding the most convenient test that can assess vitamin D status, the indications for screening, and finally the utility of treatments for vitamin D deficiency. Our review outlines practical strategies to diagnose and treat vitamin D deficiency in adults. This study was undertaken in the PubMed and the Google Scholar databases in April 2018 without limitation as to the publication period. Vitamin D status is determined by measuring the 25-hydroxyvitamin D serum concentration. However, this technique has several limitations. Determining the accurate thresholds for vitamin D deficiency is still a matter of debate. Only individuals at risk for vitamin D deficiency should be screened. The symptoms of vitamin D deficiency are unspecific and very common. Therefore, physicians may easily suspect vitamin D deficiency, measure 25-hydroxyvitamin D levels, and sometimes overprescribe supplementation. Hypovitaminosis D could rarely be treated by increasing consumption of foods naturally containing and fortified with vitamin D. Special attention should be given to vitamin D supplementation to prevent adverse effects. No safe and well-defined threshold of ultraviolet exposure allows adequate vitamin D synthesis without increasing the risk of skin cancer. Unanimous and decisive guidelines are urgently needed to improve knowledge and practices related to vitamin D deficiency.