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Related Concept Videos

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Pleura of the Lungs01:13

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The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Updated: Jan 26, 2026

Orthotopic Left Lung Transplantation in Rats
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Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

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Lung Transplantation.

Vivek N Ahya1, Joshua M Diamond2

  • 1Division of Pulmonary, Allergy and Critical Care Division, Paul F. Harron Jr. Lung Center, Penn Medicine, Perelman School of Medicine, University of Pennsylvania, 9035 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA.

The Medical Clinics of North America
|April 9, 2019
PubMed
Summary
This summary is machine-generated.

Lung transplantation can improve quality of life for end-stage lung disease patients, but complications can arise. Early referral for interstitial lung diseases, like idiopathic pulmonary fibrosis, is crucial for better outcomes.

Keywords:
AllocationComplicationsLung transplantationOutcomes

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Area of Science:

  • Pulmonology
  • Transplant Surgery
  • Immunology

Background:

  • Lung transplantation offers a therapeutic option for end-stage lung diseases, potentially improving survival and quality of life.
  • Transplant recipients face significant risks from immunologic, infectious, and medical complications.
  • Median survival post-lung transplant is approximately 6 years.

Purpose of the Study:

  • To highlight the benefits and risks associated with lung transplantation.
  • To emphasize the importance of multidisciplinary collaboration for optimizing patient outcomes.
  • To advocate for early referral for specific interstitial lung diseases.

Main Methods:

  • Review of existing literature on lung transplantation outcomes and complications.
  • Analysis of factors influencing patient survival and quality of life.
  • Clinical guidelines and expert recommendations for patient management.

Main Results:

  • Lung transplantation can extend survival and enhance quality of life for carefully selected patients.
  • Significant post-transplant complications can impede long-term success.
  • Early intervention and comprehensive care are vital for managing transplant recipients.

Conclusions:

  • Lung transplantation is a viable option for select patients with end-stage lung disease.
  • Close collaboration among patients, transplant centers, and medical teams is essential for optimizing outcomes.
  • Early referral for idiopathic pulmonary fibrosis and related interstitial lung diseases is recommended due to high risks of exacerbation and respiratory failure.