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Updated: Jan 26, 2026
Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Reflex seizure triggering: Learning about seizure producing systems
Anna Szűcs1, Beáta Rosdy2, Anna Kelemen3
1National Institute of Clinical Neurosciences, Budapest, Hungary; Semmelweis University Medical School, Heim Pál Children's Hospital, Budapest, Hungary.
Aim:
We aim to study the mechanism of reflex seizure triggering in close link with the system-epilepsy concept.
Method:
We use data and theories presented in the literature and scrutinize a few illustrative cases.
Conclusions:
The prerequisite of seizure triggering is an epilepsy-prone brain network. When it is activated, it may produce seizures manifesting the function(s) of the same system. Beyond classical reflex seizures triggered by sensory-motor stimuli, we extend the reflex-epilepsy concept to seizures induced by the normal activation of epilepsy-prone systems e.g. praxis-induced seizures and those of sleep/wake system epilepsies elicited by falling asleep (absences) or arousals from NREM sleep (seizures of genetic frontal lobe epilepsy). We suggest that normal functioning of epilepsy-prone systems may trigger seizures in epilepsies in general.
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