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Published on: April 12, 2019
Bacterial Mutagenicity of Fractions from Chloroform Extracts of Ceylon Cinnamon
1Department of Pharmaceutical Chemistry and Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Abstract:
Further to a previous report (Food Chem. Toxicol. 22:109-112, 1984) describing the presence of mutagens in a chloroform extract of Ceylon cinnamon ( Cinnamomum zeylanicum Nees), we report here our findings on the mutagenicity of silica gel column chromatographic fractions from this extract. Mutagenicity was evaluated by the rec assay using Bacillus subtillis strains H17 (rec +) and M45 (rec-). Fractions collected after elution with chloroform, chloroform-ethanol (98:2) and (95:5) exhibited mutagenicity, while those obtained by ellution with chloroform-ethanol (85:15), (75:25) and ethanol showed no such activity.
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