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2018 FDA Tides Harvest.

Danah Al Shaer1,2, Othman Al Musaimi3,4, Fernando Albericio5,6

  • 1KRISP, School of Laboratory of Medicine and Medical Science, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. 217078895@stuukznac.onmicrosoft.com.

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This summary is machine-generated.

In 2018, the US FDA approved 59 new drugs, including three TIDES (oligonucleotides and peptides). This analysis reviews their medical targets, mechanisms, structures, and economic impact.

Keywords:
LutatheraOnpattroTegsedidotatatedrugsinotersenoligonucleotidespatisiranpeptidespharmaceutical market

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Area of Science:

  • Pharmaceutical Science
  • Drug Development
  • Biotechnology

Background:

  • The US Food and Drug Administration (FDA) approved 59 novel drugs in 2018.
  • A notable subset of these approvals included three TIDES (oligonucleotides and peptides), representing 5% of the total new drugs.
  • TIDES represent a significant advancement in therapeutic modalities.

Purpose of the Study:

  • To analyze the three TIDES approved by the FDA in 2018.
  • To provide a comprehensive overview of their medical applications, mechanisms, and economic factors.

Main Methods:

  • Review of FDA drug approval data for 2018.
  • Categorization of TIDES based on chemical structure (oligonucleotides, peptides).
  • Analysis of therapeutic targets, modes of action, and economic considerations for each approved TIDE.

Main Results:

  • Two oligonucleotide-based TIDES and one peptide-based TIDE were approved.
  • The analysis details the specific medical targets and mechanisms of action for each drug.
  • Economic aspects, including market potential and pricing strategies, were evaluated.

Conclusions:

  • The 2018 FDA approvals highlight the growing importance of TIDES in medicine.
  • These novel therapeutics offer targeted treatment options with distinct mechanisms.
  • Further economic evaluation is crucial for understanding the long-term impact of TIDES.