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Cutaneous and Renal Glomerular Vasculopathy: What Do We Know so Far?
Rosanne E Jepson1, Jacqueline M Cardwell2, Stefano Cortellini1
1Department of Clinical Science and Services, Royal Veterinary College, Queen Mother Hospital for Animals, Hawkshead Lane, North Mymms, Herts, London AL9 7TA, UK.
Summary
Alabama rot, or cutaneous renal glomerular vasculopathy (CRGV), is a concerning condition in dogs. Diagnosis remains challenging, often requiring post-mortem examination of kidney tissue.
Area of Science:
- Veterinary Pathology
- Canine Medicine
- Emerging Animal Diseases
Background:
- Cutaneous renal glomerular vasculopathy (CRGV), known as Alabama rot, is an emerging disease affecting dogs.
- First identified in the UK, it has also been reported in the US and Germany.
- The etiology of CRGV remains unknown, with no confirmed infectious cause.
Purpose of the Study:
- To summarize the current understanding of cutaneous renal glomerular vasculopathy (CRGV) in dogs.
- To highlight the diagnostic challenges associated with CRGV.
- To emphasize the pathological findings crucial for confirmation.
Main Methods:
- Review of existing literature and case reports on CRGV.
- Analysis of clinical signs, including cutaneous lesions and acute kidney injury.
- Histopathological examination of renal tissue for thrombotic microangiopathy.
Main Results:
- CRGV presents initially with skin lesions.
- A subset of affected dogs develop severe acute kidney injury, potentially leading to renal failure.
- Definitive diagnosis relies on identifying thrombotic microangiopathy in kidney biopsies.
Conclusions:
- CRGV is an emerging threat to canine health with an undetermined cause.
- Early diagnosis is difficult due to the absence of specific tests.
- Renal histopathology is currently the gold standard for confirming CRGV.
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