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Updated: Jan 26, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
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Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

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Multidrug-resistant Pseudomonas aeruginosa and mortality in mechanically ventilated ICU patients

Jean-Baptiste Denis1, Samuel Lehingue1, Vanessa Pauly2

  • 1Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, Réanimation des Détresses Respiratoires et des Infections Sévères, Marseille, France.

American Journal of Infection Control
|April 10, 2019
PubMed
Abstract

Insights

This study found no link between multidrug-resistant Pseudomonas aeruginosa ventilator-associated pneumonia (MDR VAP) and patient mortality. Recurrence of VAP and underlying health conditions were associated with higher 30-day mortality rates.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Ventilator-associated pneumonia (VAP) is a significant concern, often caused by Pseudomonas aeruginosa (Pa).
  • The increasing prevalence of multidrug-resistant (MDR) pathogens like Pa complicates treatment and prognosis.
  • The relationship between bacterial resistance in VAP and patient outcomes remains unclear.

Purpose of the Study:

  • To investigate the association between episodes of MDR Pa VAP and 30-day mortality.
  • To identify factors influencing mortality in patients with Pa VAP.

Main Methods:

  • A prospective, longitudinal study using data from a French multicenter database (2010-2016).
  • MDR was defined by non-susceptibility to agents in ≥3 antimicrobial categories.
  • Multivariate survival analysis, specifically the nonlinear frailty model, was employed to assess mortality risk.

Main Results:

  • Of 286 Pa VAP episodes in 230 patients, 73 were MDR and 213 were susceptible.
  • Factors independently linked to 30-day mortality included prior hospitalization, chronic renal failure, and VAP recurrence.
  • Multidrug-resistant Pa VAP was not significantly associated with increased 30-day mortality (HR 0.87, P=0.59).

Conclusions:

  • This study found no direct relationship between the antibiotic resistance profile of Pseudomonas aeruginosa and mortality in VAP.
  • Patient prognosis in VAP is more strongly influenced by factors such as recurrence and comorbidities than by MDR status alone.
Keywords:
Empirical antiobioticIntensive care medicineMultidrug resistanceNosocomial pneumoniaRecurrenceVentilator-associated pneumonia

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