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Updated: Jan 26, 2026

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
Published on: June 25, 2019
[Significance of the endocannabinoid system in migraine]
Kinga Gecse1, Gyorgy Bagdy, Gabriella Juhasz
1SE-NAP 2 Genetikai Agyi Képalkotó Migrén Kutató Csoport, Nemzeti Agykutatási Program, Semmelweis Egyetem, Budapest, Hungary. gabriella.juhasz@manchester.ac.uk.
Abstract:
Based on the traditional pain-relieving effect of Cannabis species an endogenous cannabinoidlike system was discovered in the human body. Endocannabinoids have important role in the homeostasis of the body, such as stress response and mood control, feeding behaviour, energy balance and metabolism, immunological processes, and also play important role in controlling pain processing. Previous studies suggested that an endokannabinoid dysfunction, namely endokannabinoid deficit, might contribute to the development of migraine and its chronification. Although, the exact nature of the relationship between migraine and endokannabinoid system is not fully understood yet, in this brief review we summarise research results suggesting that the endokannabinoid system may be a potential drug target in the migraine therapy.
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