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Treatment of infant formula with patiromer dose dependently decreases potassium concentration

Neil J Paloian1, Barbara Bowman2, Sharon M Bartosh2

  • 1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, 53792, USA. npaloian@wisc.edu.

Pediatric Nephrology (Berlin, Germany)
|April 10, 2019
PubMed

Insights

Patiromer, a novel polymer, effectively reduces potassium in infant formula, offering a promising solution for managing hyperkalemia in infants with chronic kidney disease (CKD). This study demonstrates its potential for dietary potassium management.

Area of Science:

  • Nephrology
  • Pediatric Nutrition
  • Pharmaceutical Chemistry

Background:

  • Hyperkalemia is a serious risk for infants with chronic kidney disease (CKD).
  • Low-potassium infant formulas are available, but further dietary potassium restriction is often needed.
  • Patiromer, a calcium-based polymer, is a potential agent to reduce potassium in formulas, but efficacy data were lacking.

Purpose of the Study:

  • To evaluate the efficacy of patiromer in reducing potassium levels in infant formulas.
  • To assess the impact of varying patiromer doses and treatment durations on formula composition.
  • To investigate changes in other key electrolytes (calcium, sodium, magnesium, phosphorus) following patiromer treatment.

Main Methods:

  • Patiromer was added at different doses to two standard infant formulas (Similac Advance and Similac PM 60/40).
  • Potassium, calcium, sodium, magnesium, and phosphorus levels were measured at baseline and at 30 minutes, 60 minutes, and 24 hours post-administration.
  • Dose-dependent effects and time-course of ion exchange were analyzed.

Main Results:

  • Patiromer significantly decreased potassium concentrations in both formulas in a dose-dependent manner.
  • The most substantial potassium reduction occurred within 30 minutes of treatment.
  • Calcium levels increased dose-dependently, as expected, with minor changes observed in magnesium, sodium, and phosphorus.

Conclusions:

  • Pre-treatment of infant formula with patiromer effectively lowers potassium levels.
  • The ion-exchange process is rapid, with significant effects seen within 30 minutes.
  • Patiromer shows promise as a novel therapeutic option for managing hyperkalemia in infants with CKD.
Abstract

Keywords:
FormulaHyperkalemiaPatiromerPotassium

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