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Updated: Jan 26, 2026

The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation
Published on: January 31, 2025
Bone-specific kinetic model to quantify periosteal and endosteal blood flow using indocyanine green in fluorescence
Jonathan T Elliott1,2, Shudong Jiang2, Brian W Pogue2
1Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Abstract:
This letter describes a hybrid plug/compartment (HyPC) kinetic model to fit dynamic indocyanine green fluorescence data acquired in a porcine model of long bone traumatic fracture. Parametric images of periosteal blood flow, endosteal blood flow, total bone blood flow and fraction of endosteal-to-periosteal flow were obtained by applying the HyPC model on a pixel-by-pixel basis. Intraoperative discrimination between healthy and damaged bone could facilitate debridement reducing post-operative complications from non-union and infection. The ability to quantify periosteal and endosteal blood flow could inform nail vs. plate-and-screw decisions to avoid further compromising cortical blood supply.
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