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The Culture of Primary Motor and Sensory Neurons in Defined Media on Electrospun Poly-L-lactide Nanofiber Scaffolds
Published on: February 15, 2011
Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic
Ming Bi1, Hui Han2, Shujun Dong3
1Department of General Dentistry, School and Hospital of Stomatology, Jilin University, Changchun 130021, China. biming11@mails.jlu.edu.cn.
Abstract:
The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of the PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design.
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