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Updated: Jan 26, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.6K
Acalabrutinib for mantle cell lymphoma
Thomas E Witzig1, David Inwards1
1Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN.
Blood
|April 11, 2019
Summary
Acalabrutinib, a targeted therapy, shows high effectiveness in treating relapsed mantle cell lymphoma (MCL). This Bruton tyrosine kinase inhibitor offers a new option for MCL patients, with ongoing research for upfront treatment.
Area of Science:
- Oncology
- Hematology
- Pharmacology
Background:
- Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma.
- MCL is defined by cyclin D1 overexpression and often involves multiple relapses.
- Existing treatments for relapsed MCL have limitations.
Purpose of the Study:
- To evaluate the efficacy of acalabrutinib in patients with relapsed MCL.
- To assess acalabrutinib as a novel treatment option for MCL.
Main Methods:
- A clinical trial was conducted to assess acalabrutinib's effectiveness.
- Acalabrutinib, a Bruton tyrosine kinase inhibitor, was administered orally.
- Overall response rate was a key efficacy endpoint.
Main Results:
- Acalabrutinib demonstrated a high overall response rate of 81% in relapsed MCL.
- The drug is a second-generation, targeted oral therapy.
- Positive results support its approval for relapsed MCL.
Conclusions:
- Acalabrutinib is an effective treatment for relapsed MCL.
- It represents a significant advancement in MCL therapy.
- Further investigation is underway for its use in upfront MCL treatment.
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