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Updated: Jan 26, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma
Weidong He1, Ming Lu2, Dongbo Xiao3
1Department of Joint Surgery, The First People's Hospital of Lianyungang, Lianyungang 222002, Jiangsu, China.
Long stress-induced non-coding transcript 5 (LSINCT5) is upregulated in osteosarcoma, promoting cancer progression. High LSINCT5 expression predicts poor survival and drives tumor growth, migration, and invasion.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Dysregulated expression of long stress-induced non-coding transcript 5 (LSINCT5) is linked to various human cancers.
- Previous studies on LSINCT5 in osteosarcoma had limited sample sizes.
Purpose of the Study:
- To investigate the clinical significance and biological function of LSINCT5 in osteosarcoma.
- To provide further evidence for LSINCT5's role in osteosarcoma progression.
Main Methods:
- Quantitative analysis of LSINCT5 expression in osteosarcoma tissues and cell lines.
- Correlation analysis between LSINCT5 expression and clinical parameters (Enneking stage, tumor size, grade, metastasis).
- In vitro experiments assessing the effects of LSINCT5 inhibition and overexpression on cell proliferation, migration, and invasion.
Main Results:
- LSINCT5 expression was significantly increased in osteosarcoma samples and cell lines.
- High LSINCT5 expression correlated with advanced stage, larger tumor size, higher grade, and distant metastasis.
- High LSINCT5 expression was an independent predictor of worse overall survival.
- LSINCT5 inhibition suppressed, while overexpression enhanced, osteosarcoma cell proliferation, migration, and invasion.
Conclusions:
- LSINCT5 possesses oncogenic functions in osteosarcoma cells.
- LSINCT5 may serve as a potential prognostic biomarker for osteosarcoma patients.
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