Related Experiment Video
Updated: Jan 26, 2026
04:30
An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
Published on: October 25, 2019
6.0K
Effects of apoptosis on liver aging
Shao-Jie Hu1, Sha-Sha Jiang1, Jin Zhang1
1Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China.
World Journal of Clinical Cases
|April 11, 2019
Summary
Aging impairs liver function and regeneration. Apoptosis, a programmed cell death, plays a dual role, eliminating abnormal cells but also driving age-related liver diseases like fibrosis and cancer.
Area of Science:
- Hepatology
- Gerontology
- Cell Biology
Background:
- Aging leads to organ decline, including reduced liver volume and blood flow.
- The aging liver's regenerative capacity and metabolic functions diminish.
- Apoptosis (programmed cell death) is a key process involving Bcl-2 family proteins and genes like p21 and p53.
Purpose of the Study:
- To summarize the multifaceted roles of apoptosis in liver aging.
- To explore the impact of apoptosis on age-related liver diseases.
Main Methods:
- Literature review and synthesis of existing research on apoptosis and liver aging.
- Analysis of the molecular pathways of apoptosis (intrinsic and extrinsic).
Main Results:
- Apoptosis contributes to liver aging by eliminating abnormal cells.
- Apoptosis exacerbates age-related liver conditions, including nonalcoholic fatty liver disease, fibrosis, cirrhosis, and cancer.
Conclusions:
- Apoptosis has a dual effect on liver aging, with both protective and detrimental consequences.
- Understanding apoptosis's role is crucial for managing age-related liver diseases.
More Related Videos
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
193
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
193
01:30Apoptosis
14.3K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
14.3K
01:26Aging
659
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
659
01:19The Effect of Aging on Tissues
3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
01:09Changes in the Appendicular Skeleton with Age
3.4K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
02:19Buffer Effectiveness
55.0K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.0K