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Updated: Jan 26, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
The kneeling test is a valid method of assessing kneeling tolerance
Nicholas D Calvert1, Anne Smith2, Lukas Kuster3
1Department of Orthopaedics, Royal Perth Hospital, Wellington Street, Perth, WA, 6000, Australia. Nicholas.Calvert@health.wa.gov.au.
A new kneeling test accurately quantifies knee function and pain tolerance in patients with osteoarthritis or after surgery. This validated tool can help assess outcomes and refine surgical methods for better patient results.
Area of Science:
- Orthopedics
- Biomedical Engineering
- Rehabilitation Science
Background:
- Quantitative assessment of kneeling tolerance is lacking, hindering pre- and post-surgical evaluation.
- Kneeling is a common functional activity affected by knee conditions and surgeries.
Purpose of the Study:
- To validate a novel kneeling test designed to quantitatively measure kneeling tolerance.
- To assess the test's reliability and validity in various patient populations.
Main Methods:
- 179 participants (324 knees) including asymptomatic, osteoarthritis (OA), total knee arthroplasty (TKA), and anterior cruciate ligament reconstruction (ACLR) groups.
- Kneeling performed on a custom platform at 90° and 110° flexion on varied surfaces, with a 0-100 pain/discomfort score.
- Statistical analysis included mixed models, Pearson's correlation with FJS/WOMAC, and intraclass correlation coefficient (ICC) for reliability.
Main Results:
- The kneeling test showed good discriminative validity, differentiating between asymptomatic knees and those with OA, ACLR, or TKA at both 90° and 110° (p < 0.013).
- Strong correlations were found between the kneeling test and FJS/WOMAC scores, supporting construct validity (e.g., 110° FJS: 0.579, WOMAC: -0.648).
- High test-retest reliability was demonstrated, with ICC values of 0.843 at 90° and 0.926 at 110°.
Conclusions:
- The developed kneeling test is a valid and reliable method for quantitatively assessing kneeling tolerance.
- This tool can assist in evaluating surgical outcomes and guiding modifications to improve patient function and satisfaction.
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