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Effects of Lactobacillus rhamnosus GG as a probiotic on neonatal hyperbilirubinemia

Mehmet Mutlu1, Erdal Irmak2, Yakup Aslan1

  • 1Division of Neonatology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.

The Turkish Journal of Pediatrics
|April 11, 2019
PubMed

Insights

Probiotic supplementation with Lactobacillus rhamnosus GG given to newborns immediately after birth significantly lowered total bilirubin levels. This probiotic intervention also increased defecation frequency, suggesting a role in managing neonatal hyperbilirubinemia.

Area of Science:

  • Neonatology
  • Microbiology
  • Pediatrics

Background:

  • Neonatal hyperbilirubinemia is often linked to immature gut microbiota and increased enterohepatic circulation.
  • Early life intestinal microflora development plays a crucial role in infant health.

Purpose of the Study:

  • To investigate the effect of early probiotic supplementation on neonatal hyperbilirubinemia.
  • To determine if Lactobacillus rhamnosus GG can influence bilirubin metabolism in newborns.

Main Methods:

  • A randomized controlled trial involving 150 healthy term newborns.
  • The study group received Lactobacillus rhamnosus GG drops daily for 10 days post-birth.
  • The control group received saline drops, and serum bilirubin levels and defecation frequency were monitored.

Main Results:

  • Newborns receiving Lactobacillus rhamnosus GG showed significantly lower mean total bilirubin levels on days 3, 5, and 10.
  • Defecation frequency was significantly higher in the probiotic group compared to controls.
  • A significant negative correlation was observed between defecation frequency and total bilirubin levels.

Conclusions:

  • Early initiation of Lactobacillus rhamnosus GG probiotic support positively impacts bilirubin metabolism.
  • Probiotic intervention may be a viable strategy to reduce the risk of neonatal hyperbilirubinemia.

Keywords:
hyperbilirubinemiameconiumnewbornprobiotic

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