Initial clinical outcomes and prognostic variables in the implementation of a Code Sepsis in a high complexity...

Area of Science:

• Critical Care Medicine
• Hospital Quality Improvement
• Sepsis Management

Background:

• Sepsis remains a leading cause of hospital mortality.
• Effective sepsis management protocols, such as Code Sepsis, are crucial for improving patient outcomes.
• Assessing the early impact of such interventions is vital for evidence-based refinement.

Purpose of the Study:

• To evaluate the initial implementation and impact of a Code Sepsis protocol in a high-complexity hospital.
• To analyze the epidemiological and clinical characteristics of sepsis patients.
• To identify prognostic factors associated with mortality in sepsis.

Main Methods:

• A seven-month observational study (February 2015 - September 2015) included 237 consecutive sepsis patients.
• Uni- and multivariate analyses were employed to determine the relationship between risk factors, analytic values, and mortality.
• Data collected included patient demographics, clinical characteristics, laboratory values, and severity scores.

Main Results:

• In-hospital mortality was 24% at 30 days and 27% at 60 days, with 30% mortality in Critical Care Units.
• Significant differences in creatinine, lactic acid, and procalcitonin levels were observed between survivors and non-survivors.
• Independent risk factors for death included age > 65 years, elevated lactic acid (> 3 mmol/L), elevated creatinine (> 1.2 mg/dL), and shock.

Conclusions:

• The epidemiological and clinical profile of sepsis patients in this series aligns with existing literature.
• Specific biomarkers and clinical factors (age, creatinine, lactic acid, shock) were identified as valuable local predictors of sepsis mortality.
• Continuous evaluation and improvement of Code Sepsis programs are essential for optimizing patient care and reducing mortality.