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Updated: Jan 26, 2026

Generating Self-Assembling Human Heart Organoids Derived from Pluripotent Stem Cells
Published on: September 15, 2021
User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a
Oliver Schneider1, Lisa Zeifang1, Stefanie Fuchs1
11 Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany.
Impact Statement:
With the ultimate goal in tissue engineering of approaching in vivo functionality as closely as possible, organ-on-a-chip (OoC) systems provide unprecedented game-changing opportunities by enabling creation of perfused three-dimensional tissues. Most of the recently developed OoC systems, however, require complex handling steps. Hence, a large gap still exists between technology development and collection of valuable biological data in a standardized medium- or high-throughput manner. The system presented here bridges this gap by providing a user-friendly framework for the parallelized creation of multiple physiologically relevant tissues, which could be applicable in every laboratory without additional equipment.
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