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Related Experiment Video

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Evaluating the Function of the Foot Core System in the Elderly

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Published on: March 11, 2022

Association between epicardial fat thickness and cognitive function in elderly. A preliminary study.

Walter Verrusio¹, Alessia Renzi², Valerio Massimo Magro³

¹Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Sapienza Università di Roma, Rome, Italy.

Annali Dell'Istituto Superiore Di Sanita

|April 11, 2019

Summary

Increased epicardial adipose tissue (EAT) thickness, a marker of visceral fat, is linked to poorer cognitive function. This study found higher EAT levels predict lower scores on cognitive tests, suggesting a role in cognitive impairment.

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In Vitro Culture of Epicardial Cells From Mouse Embryonic Heart

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Published on: April 27, 2016

Area of Science:

Cardiology
Neurology
Metabolic Syndrome

Background:

Visceral fat accumulation, particularly epicardial adipose tissue (EAT), is increasingly implicated in the development of dementia.
Understanding the relationship between EAT and cognitive decline is crucial for early detection and prevention strategies.

Purpose of the Study:

To investigate differences in metabolic and cognitive variables between individuals with varying epicardial adipose tissue (EAT) thickness.
To determine the predictive value of EAT levels for cognitive functioning.

Main Methods:

A cohort of 65 community-dwelling subjects was divided into two groups based on EAT thickness (< 7 mm and > 7 mm).
Transthoracic echocardiography was used to measure EAT thickness, and biochemical parameters assessed metabolic profiles.
Cognitive function was evaluated using the Mini Mental State Examination (MMSE).

Main Results:

Significant differences were observed between the EAT groups, including variations in MMSE scores.
Multiple linear regression analysis revealed that EAT thickness and hypertension were significant predictors of MMSE scores.
Higher EAT thickness was associated with lower cognitive performance.

Conclusions:

Preliminary evidence suggests a significant association between increased epicardial adipose tissue thickness and cognitive impairment.
EAT may serve as a potential biomarker for identifying individuals at risk of cognitive decline.