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Immunotherapy in first-line for advanced non-small cell lung cancer: a cost-effective choice?
Jacopo Giuliani1, Andrea Bonetti1
1Department of Oncology, Mater Salutis Hospital, Az. ULSS 9 Scaligera, Legnago (VR), Italy.
Introduction:
The present evaluation was restricted to pivotal phase III randomized controlled trials (RCTs) in first-line for metastatic non-small cell lung cancer (NSCLC).
Materials And Methods:
We calculated the pharmacological costs necessary to get the benefit in overall survival (OS), for each trial.
Results:
Our analysis evaluated 10 phase III RCTs, including 9485 patients. The most relevant increase of cost € per month of OS-gain was associated with bevacizumab (66,720 €) and the lowest with the use of pembrolizumab (2734 €).
Conclusion:
Combining pharmacological costs of drugs with the measure of efficacy represented by OS, pembrolizumab is a cost-effective first-line treatment for patients with metastatic NSCLC.
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Extraction: Advanced Methods
Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.

